Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain.
Identifieur interne : 000266 ( Main/Exploration ); précédent : 000265; suivant : 000267Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain.
Auteurs : Simona Iftimie [Espagne] ; Ana F. L Pez-Azcona [Espagne] ; Manuel Vicente-Miralles [Espagne] ; Ramon Descarrega-Reina [Espagne] ; Anna Hernández-Aguilera [Espagne] ; Francesc Riu [Espagne] ; Josep M. Sim [Espagne] ; Pedro Garrido [Espagne] ; Jorge Joven [Espagne] ; Jordi Camps [Espagne] ; Antoni Castro [Espagne]Source :
- PloS one [ 1932-6203 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Comorbidité (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (épidémiologie), Mortalité hospitalière (MeSH), Mâle (MeSH), Nourrisson (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (épidémiologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études longitudinales (MeSH), Études prospectives (MeSH).
- MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Adolescent, Adulte, Adulte d'âge moyen, Comorbidité, Enfant, Enfant d'âge préscolaire, Espagne, Femelle, Humains, Mortalité hospitalière, Mâle, Nourrisson, Pandémies, Sujet âgé, Sujet âgé de 80 ans ou plus, Études longitudinales, Études prospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Child (MeSH), Child, Preschool (MeSH), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Infant (MeSH), Longitudinal Studies (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Prospective Studies (MeSH), Spain (MeSH).
- MESH :
- geographic : Spain.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Comorbidity, Female, Hospital Mortality, Humans, Infant, Longitudinal Studies, Male, Middle Aged, Pandemics, Prospective Studies.
Abstract
Spain is one of the countries that has suffered the most from the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain that causes coronavirus disease 2019 (COVID-19). However, there is a lack of information on the characteristics of this disease in the Spanish population. The objective of this study has been to characterize our patients from an epidemiological point of view and to identify the risk factors associated with mortality in our geographical area. We performed a prospective, longitudinal study on 188 hospitalized cases of SARS-Cov-2 infection in Hospital Universitari de Sant Joan, in Reus, Spain, admitted between 15th March 2020 and 30th April 2020. We recorded demographic data, signs and symptoms and comorbidities. We also calculated the Charlson and McCabe indices. A total of 43 deaths occurred during the study period. Deceased patients were older than the survivors (77.7 ± 13.1 vs. 62.8 ± 18.4 years; p < 0.001). Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. The Charlson index was more efficient than the McCabe index in discriminating between deceased and survivors. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. We identified the main factors independently associated with mortality in our population. Further studies are needed to complete and confirm our findings.
DOI: 10.1371/journal.pone.0234452
PubMed: 32881860
PubMed Central: PMC7470256
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Sim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratori de Referència del Camp de Tarragona i Terres de l'Ebre, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratori de Referència del Camp de Tarragona i Terres de l'Ebre, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Garrido, Pedro" sort="Garrido, Pedro" uniqKey="Garrido P" first="Pedro" last="Garrido">Pedro Garrido</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Intensive Care Unit, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Joven, Jorge" sort="Joven, Jorge" uniqKey="Joven J" first="Jorge" last="Joven">Jorge Joven</name><affiliation wicri:level="1"><nlm:affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Camps, Jordi" sort="Camps, Jordi" uniqKey="Camps J" first="Jordi" last="Camps">Jordi Camps</name><affiliation wicri:level="1"><nlm:affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Castro, Antoni" sort="Castro, Antoni" uniqKey="Castro A" first="Antoni" last="Castro">Antoni Castro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32881860</idno><idno type="pmid">32881860</idno><idno type="doi">10.1371/journal.pone.0234452</idno><idno type="pmc">PMC7470256</idno><idno type="wicri:Area/Main/Corpus">000361</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000361</idno><idno type="wicri:Area/Main/Curation">000361</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000361</idno><idno type="wicri:Area/Main/Exploration">000361</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain.</title><author><name sortKey="Iftimie, Simona" sort="Iftimie, Simona" uniqKey="Iftimie S" first="Simona" last="Iftimie">Simona Iftimie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Azcona, Ana F" sort="L Pez Azcona, Ana F" uniqKey="L Pez Azcona A" first="Ana F" last="L Pez-Azcona">Ana F. L Pez-Azcona</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Vicente Miralles, Manuel" sort="Vicente Miralles, Manuel" uniqKey="Vicente Miralles M" first="Manuel" last="Vicente-Miralles">Manuel Vicente-Miralles</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Descarrega Reina, Ramon" sort="Descarrega Reina, Ramon" uniqKey="Descarrega Reina R" first="Ramon" last="Descarrega-Reina">Ramon Descarrega-Reina</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez Aguilera, Anna" sort="Hernandez Aguilera, Anna" uniqKey="Hernandez Aguilera A" first="Anna" last="Hernández-Aguilera">Anna Hernández-Aguilera</name><affiliation wicri:level="1"><nlm:affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Riu, Francesc" sort="Riu, Francesc" uniqKey="Riu F" first="Francesc" last="Riu">Francesc Riu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Sim, Josep M" sort="Sim, Josep M" uniqKey="Sim J" first="Josep M" last="Sim">Josep M. Sim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratori de Referència del Camp de Tarragona i Terres de l'Ebre, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratori de Referència del Camp de Tarragona i Terres de l'Ebre, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Garrido, Pedro" sort="Garrido, Pedro" uniqKey="Garrido P" first="Pedro" last="Garrido">Pedro Garrido</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Intensive Care Unit, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Joven, Jorge" sort="Joven, Jorge" uniqKey="Joven J" first="Jorge" last="Joven">Jorge Joven</name><affiliation wicri:level="1"><nlm:affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Camps, Jordi" sort="Camps, Jordi" uniqKey="Camps J" first="Jordi" last="Camps">Jordi Camps</name><affiliation wicri:level="1"><nlm:affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author><author><name sortKey="Castro, Antoni" sort="Castro, Antoni" uniqKey="Castro A" first="Antoni" last="Castro">Antoni Castro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus</wicri:regionArea><wicri:noRegion>Reus</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Female (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Longitudinal Studies (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Prospective Studies (MeSH)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Comorbidité (MeSH)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (épidémiologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études longitudinales (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Comorbidity</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Infant</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Espagne</term><term>Femelle</term><term>Humains</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Nourrisson</term><term>Pandémies</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études longitudinales</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Spain is one of the countries that has suffered the most from the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain that causes coronavirus disease 2019 (COVID-19). However, there is a lack of information on the characteristics of this disease in the Spanish population. The objective of this study has been to characterize our patients from an epidemiological point of view and to identify the risk factors associated with mortality in our geographical area. We performed a prospective, longitudinal study on 188 hospitalized cases of SARS-Cov-2 infection in Hospital Universitari de Sant Joan, in Reus, Spain, admitted between 15th March 2020 and 30th April 2020. We recorded demographic data, signs and symptoms and comorbidities. We also calculated the Charlson and McCabe indices. A total of 43 deaths occurred during the study period. Deceased patients were older than the survivors (77.7 ± 13.1 vs. 62.8 ± 18.4 years; p < 0.001). Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. The Charlson index was more efficient than the McCabe index in discriminating between deceased and survivors. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. We identified the main factors independently associated with mortality in our population. Further studies are needed to complete and confirm our findings.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32881860</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>9</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain.</ArticleTitle><Pagination><MedlinePgn>e0234452</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0234452</ELocationID><Abstract><AbstractText>Spain is one of the countries that has suffered the most from the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the strain that causes coronavirus disease 2019 (COVID-19). However, there is a lack of information on the characteristics of this disease in the Spanish population. The objective of this study has been to characterize our patients from an epidemiological point of view and to identify the risk factors associated with mortality in our geographical area. We performed a prospective, longitudinal study on 188 hospitalized cases of SARS-Cov-2 infection in Hospital Universitari de Sant Joan, in Reus, Spain, admitted between 15th March 2020 and 30th April 2020. We recorded demographic data, signs and symptoms and comorbidities. We also calculated the Charlson and McCabe indices. A total of 43 deaths occurred during the study period. Deceased patients were older than the survivors (77.7 ± 13.1 vs. 62.8 ± 18.4 years; p < 0.001). Logistic regression analyses showed that fever, pneumonia, acute respiratory distress syndrome, diabetes mellitus and cancer were the variables that showed independent and statistically significant associations with mortality. The Charlson index was more efficient than the McCabe index in discriminating between deceased and survivors. This is one of the first studies to describe the factors associated with mortality in patients infected with SARS-CoV-2 in Spain, and one of the few in the Mediterranean area. We identified the main factors independently associated with mortality in our population. Further studies are needed to complete and confirm our findings.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Iftimie</LastName><ForeName>Simona</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-Azcona</LastName><ForeName>Ana F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vicente-Miralles</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Descarrega-Reina</LastName><ForeName>Ramon</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernández-Aguilera</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riu</LastName><ForeName>Francesc</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pathology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simó</LastName><ForeName>Josep M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Laboratori de Referència del Camp de Tarragona i Terres de l'Ebre, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garrido</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joven</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camps</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-3165-3640</Identifier><AffiliationInfo><Affiliation>Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="Y">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32881860</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0234452</ArticleId><ArticleId IdType="pii">PONE-D-20-15853</ArticleId><ArticleId IdType="pmc">PMC7470256</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Ann Oncol. 2020 Jul;31(7):894-901</Citation><ArticleIdList><ArticleId IdType="pubmed">32224151</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Nucl Med Mol Imaging. 2020 May;47(5):1275-1280</Citation><ArticleIdList><ArticleId IdType="pubmed">32107577</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Mar 26;382(13):1199-1207</Citation><ArticleIdList><ArticleId IdType="pubmed">31995857</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS J. 2020 Mar 18;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32189428</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Mar 21;395(10228):931-934</Citation><ArticleIdList><ArticleId IdType="pubmed">32164834</ArticleId></ArticleIdList></Reference><Reference><Citation>Thorax. 2003 May;58(5):377-82</Citation><ArticleIdList><ArticleId IdType="pubmed">12728155</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Ophthalmol. 2020 May 1;138(5):575-578</Citation><ArticleIdList><ArticleId IdType="pubmed">32232433</ArticleId></ArticleIdList></Reference><Reference><Citation>Nicotine Tob Res. 2020 Aug 24;22(9):1669-1670</Citation><ArticleIdList><ArticleId IdType="pubmed">32383751</ArticleId></ArticleIdList></Reference><Reference><Citation>Viruses. 2020 Mar 27;12(4):</Citation><ArticleIdList><ArticleId IdType="pubmed">32230900</ArticleId></ArticleIdList></Reference><Reference><Citation>Intern Emerg Med. 2020 Aug;15(5):845-852</Citation><ArticleIdList><ArticleId IdType="pubmed">32385628</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2020 Apr 11;395(10231):1225-1228</Citation><ArticleIdList><ArticleId IdType="pubmed">32178769</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Infect Dis. 2020 Apr;93:201-204</Citation><ArticleIdList><ArticleId IdType="pubmed">32097725</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2016 Feb 23;315(8):801-10</Citation><ArticleIdList><ArticleId IdType="pubmed">26903338</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation><ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId></ArticleIdList></Reference><Reference><Citation>AIDS Behav. 2020 Aug;24(8):2253-2257</Citation><ArticleIdList><ArticleId IdType="pubmed">32342259</ArticleId></ArticleIdList></Reference><Reference><Citation>J Public Health Res. 2016 Dec 21;5(3):733</Citation><ArticleIdList><ArticleId IdType="pubmed">28083520</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Oncol. 2020 Jul 1;6(7):1108-1110</Citation><ArticleIdList><ArticleId IdType="pubmed">32211820</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabet Med. 2006 Jun;23(6):623-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16759303</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Ophthalmol. 2020 Jun;104(6):748-751</Citation><ArticleIdList><ArticleId IdType="pubmed">32265202</ArticleId></ArticleIdList></Reference><Reference><Citation>Medicine (Baltimore). 2015 Sep;94(36):e1474</Citation><ArticleIdList><ArticleId IdType="pubmed">26356705</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Clin Oncol. 2020 Jun;17(6):336</Citation><ArticleIdList><ArticleId IdType="pubmed">32265531</ArticleId></ArticleIdList></Reference><Reference><Citation>Isr Med Assoc J. 2020 May;22(5):271-274</Citation><ArticleIdList><ArticleId IdType="pubmed">32378815</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 1992 Dec 15;117(12):1003-9</Citation><ArticleIdList><ArticleId IdType="pubmed">1443968</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Chem. 1993 Apr;39(4):561-77</Citation><ArticleIdList><ArticleId IdType="pubmed">8472349</ArticleId></ArticleIdList></Reference><Reference><Citation>CNS Neurosci Ther. 2020 May;26(5):499-501</Citation><ArticleIdList><ArticleId IdType="pubmed">32266761</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Oncol. 2020 Apr;21(4):e180</Citation><ArticleIdList><ArticleId IdType="pubmed">32142622</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes Ther. 2020 May 7;:1-3</Citation><ArticleIdList><ArticleId IdType="pubmed">32382358</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Geriatr Soc. 2020 Jun;68(6):E19-E23</Citation><ArticleIdList><ArticleId IdType="pubmed">32383809</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2020 Jun;80(6):e14-e18</Citation><ArticleIdList><ArticleId IdType="pubmed">32171866</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 1993 Dec 22-29;270(24):2957-63</Citation><ArticleIdList><ArticleId IdType="pubmed">8254858</ArticleId></ArticleIdList></Reference><Reference><Citation>South Med J. 2008 Nov;101(11):1086</Citation><ArticleIdList><ArticleId IdType="pubmed">19088511</ArticleId></ArticleIdList></Reference><Reference><Citation>South Med J. 2008 Nov;101(11):1141-5; quiz 1132, 1179</Citation><ArticleIdList><ArticleId IdType="pubmed">19088525</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2020 Jun;127:104378</Citation><ArticleIdList><ArticleId IdType="pubmed">32353762</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Cardiol. 2020 May;17(5):259-260</Citation><ArticleIdList><ArticleId IdType="pubmed">32139904</ArticleId></ArticleIdList></Reference><Reference><Citation>Ear Nose Throat J. 2020 Apr 13;:145561320920762</Citation><ArticleIdList><ArticleId IdType="pubmed">32283980</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Negl Trop Dis. 2020 May 8;14(5):e0008280</Citation><ArticleIdList><ArticleId IdType="pubmed">32384078</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Med (Lausanne). 2020 Apr 24;7:170</Citation><ArticleIdList><ArticleId IdType="pubmed">32391369</ArticleId></ArticleIdList></Reference><Reference><Citation>Mech Ageing Dev. 2020 Jun;188:111255</Citation><ArticleIdList><ArticleId IdType="pubmed">32353398</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Iftimie, Simona" sort="Iftimie, Simona" uniqKey="Iftimie S" first="Simona" last="Iftimie">Simona Iftimie</name></noRegion><name sortKey="Camps, Jordi" sort="Camps, Jordi" uniqKey="Camps J" first="Jordi" last="Camps">Jordi Camps</name><name sortKey="Castro, Antoni" sort="Castro, Antoni" uniqKey="Castro A" first="Antoni" last="Castro">Antoni Castro</name><name sortKey="Descarrega Reina, Ramon" sort="Descarrega Reina, Ramon" uniqKey="Descarrega Reina R" first="Ramon" last="Descarrega-Reina">Ramon Descarrega-Reina</name><name sortKey="Garrido, Pedro" sort="Garrido, Pedro" uniqKey="Garrido P" first="Pedro" last="Garrido">Pedro Garrido</name><name sortKey="Hernandez Aguilera, Anna" sort="Hernandez Aguilera, Anna" uniqKey="Hernandez Aguilera A" first="Anna" last="Hernández-Aguilera">Anna Hernández-Aguilera</name><name sortKey="Hernandez Aguilera, Anna" sort="Hernandez Aguilera, Anna" uniqKey="Hernandez Aguilera A" first="Anna" last="Hernández-Aguilera">Anna Hernández-Aguilera</name><name sortKey="Joven, Jorge" sort="Joven, Jorge" uniqKey="Joven J" first="Jorge" last="Joven">Jorge Joven</name><name sortKey="L Pez Azcona, Ana F" sort="L Pez Azcona, Ana F" uniqKey="L Pez Azcona A" first="Ana F" last="L Pez-Azcona">Ana F. L Pez-Azcona</name><name sortKey="Riu, Francesc" sort="Riu, Francesc" uniqKey="Riu F" first="Francesc" last="Riu">Francesc Riu</name><name sortKey="Sim, Josep M" sort="Sim, Josep M" uniqKey="Sim J" first="Josep M" last="Sim">Josep M. Sim</name><name sortKey="Vicente Miralles, Manuel" sort="Vicente Miralles, Manuel" uniqKey="Vicente Miralles M" first="Manuel" last="Vicente-Miralles">Manuel Vicente-Miralles</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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